Word: molecular
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...proteins called amyloid beta-derived diffusible ligands (ADDLs, for short), which are known to pile up in the brains of people with Alzheimer's. Scientists also knew that Alzheimer's patients' brains have lower levels of insulin and are insulin resistant. But what the Northwestern team discovered is the molecular mechanism behind that resistance: when ADDLs bind to neurons at synapses, they obliterate the receptors that are normally reserved for insulin. Without those parking spaces on the brain cells' surface, insulin has no place to connect, and memory fails...
...hoped the event would help break down Harvard’s “culture of mutual avoidance.” Seated casually on sofas in the Barker Center, professors shared comical anecdotes about students who came to office hours, recalling one pupil whom Professor of the Practice of Molecular and Cellular Biology Robert A. Lue nicknamed “The Ocean” for his relentless stream of questions. 300th Anniversary University Professor Laurel Thatcher Ulrich, a Pulitzer Prize-winning historian, hastened to add that students don’t need to come in with a specific question...
...earlier this year to support developing nations by providing new technologies, the Harvard Technology Development Office and a microbiology researcher have agreed to help distribute novel vaccine-production techniques to communities in need. John J. Mekalanos, chair of the Harvard Medical School’s Department of Microbiology and Molecular Genetics, developed a cheaper, faster technique for manufacturing conjugate vaccines, which protect against multiple diseases caused by bacteria such as pneumococcus, which can cause everything from ear infections to pneumonia. The vaccines’ capacity to protect against a variety of diseases at once makes them particularly valuable in developing...
Capecchi ultimately found his way to Harvard, the center of the universe in the early days of molecular biology. But he felt crowded by colleagues whose rivalries consumed them as much as their research. So he set off for the University of Utah, where the sight lines suited him better and collegiality was the key to success. He lives in a house high over a canyon. "I love looking across long distances," he says. "I think it sort of opens up my mind...
...elderly Reynolds was still president of the Royal Academy when the 14-year-old Turner was admitted to the Academy's school. But Turner would have been a disaster as a portraitist. He could draw as well as the best of them. In watercolor he could produce something like molecular detail, notwithstanding that one of his typical techniques was to soak the entire sheet in water, rub in raw pigment, blot it with rags and sponges and then painstakingly work up finer detail within the misty blooms of color. Yet as he matured, his deepest impulse wasn't to delineate...