Word: molinoff
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...fried stuff has a zesty flavor,” says Jenny Wong ’08. Meanwhile, Sarah E. Molinoff ’08 takes issue with the presentation of her meal. “Everything is good, but they put all the fried stuff on a napkin and with the grease it all sort of melts together. I ended up eating napkin...
Students, however, give the background music mixed reviews. “We tried to play Oasis on the grill’s jukebox and then it automatically started playing the Supremes for like a half an hour—which was overdose,” complains Molinoff...
...present, the likelihood that this particular vaccine or this particular secretase inhibitor will end up in the therapeutic arsenal has to be considered slim. Of all the compounds his team brings forward, says Molinoff, only 10% to 15% manage to pass the rigorous series of tests that lead to approval by the U.S. Food and Drug Administration. And even when they do, Harvard University neurologist Dr. Kenneth Kosik emphasizes, precious few new drugs prove to be anything close to magic bullets. Indeed, Kosik, along with many others, thinks it is quite likely that controlling Alzheimer's disease will require more...
...more than 100,000 candidates in the initial screen, says Molinoff, head of neuroscience drug discovery at Bristol-Myers Squibb, only two were deemed promising enough to continue working on. That was in 1996. Now, thanks to the efforts of nearly 40 scientists--some at Bristol-Myers' Wallingford, Conn., research institute, others at SIBIA Neurosciences, based in La Jolla, Calif.--the number of compounds derived from these two templates has expanded to more than a thousand...
...used to think plaques were like bits of concrete scattered throughout the brain," says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his co-workers at Elan have developed. In 1999 they administered their vaccine to mice whose brains were filled with plaques. A short time later, the plaques shrank. Currently the Elan vaccine, like the Bristol-Myers' secretase inhibitor, is in early-phase clinical trials, in which the primary objective is to test...