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The Bulldogs threatened in the final frame when batter Mariclaire Rebman led off with a strikeout but was able to reach first on a wild pitch by Zumbro. After a single and a flyout that put runners on second and third, another single and a groundout brought in two runs...
Tuberculosis: The very name of the disease evokes images of antiquity, a footnote in dusty encyclopedias of human sickness overshadowed by the abbreviated diseases of the present—SARS, HIV/AIDS, H1N1. Few students would be able to guess that one third of the world’s population is...
After a long period of decline, TB incidence has risen dramatically since the 1980s, despite the improvement of sanitary conditions, the development of anti-TB drugs in the 1950s, and the introduction of the World Health Organization’s directly-observed treatment short-course program for more effective treatment...
First, the current treatment regimen requires patients take a cocktail of four drugs, all nearly half a century old, for at least six months. The logistical and financial hurdles associated with paying for and completing treatment, however, virtually guarantee noncompliance and relapse. Second, in a cascade effect, noncompliance selects for...
New therapeutic regimens represent, however, only half the solution. Without commensurate scale-up of community-based treatment programs—the “social” dimension of treatment—or reform of inefficient drug delivery mechanisms in developing countries, TB treatment will remain inaccessible, ineffective, and ultimately...