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Penicillin Deaths. After going through the catalogue of drugs that cause severe or fatal breakdowns in the blood-forming mechanism, Dr. Moser reminded his audience that one of the worst drug offenders of all remains one of the most valuable lifesavers available: penicillin. It is known to set off an infinite variety of allergic or "serum sickness" reactions, and causes up to 300 U.S. deaths a year. Even the mildest of drug-induced difficulties, he added, should not be minimized, for the side effects are not limited to one generation. If a woman has certain radiopaque dyes injected for gall...
Each drug is designed to act upon a particular organ or upon particular tissues. But as Lieut. Colonel Robert H. Moser of the Army Medical Corps told a Palo Alto, Calif., symposium on "Diseases of Medical Progress": "We are inclined to forget that the drug is also in contact with other tissues. Effects in those areas are not immediately evident: subtle influences may be at work and may become manifest only later." Such long-range effects, Dr. Moser warned, may never be traced to the drug that caused them. "This is a shadow world of pathophysiology, where relation of cause...
Despite that difficulty, Moser made a devastating indictment of almost every class of new drug. The cortisone-type hormones, familiar for their wide use, particularly in rheumatic disorders, have long since been convicted of causing or exacerbating peptic ulcers, of giving users a fattened "moon" face, and growing mustaches on women. Colonel Moser emphasized two severe unpleasant side effects that may go undetected. Given to victims of leukemia or Hodgkin's disease, he said, these hormones predispose the patients to fungus infections, and they leach the calcium out of the bones of the bedridden elderly...
...disease reactions that doctors describe as "pharmacogenetic." In these cases a drug may have no detectable harmful effect upon the vast majority of members of one ethnic group; yet because of a hereditary quirk, some individuals will be made gravely ill. Best example, said Dr. Moser, is the tendency-rare in the general U.S. population-to a blood-destroying anemia that can develop after taking aspirin or phenacetin (compounded together in the familiar APC tablets), some sulfonamides, and drugs for the relief of peptic ulcer...
Harvard heavyweight Tack Chace also contributed a pin by quickly squashing M.I.T.'s Harry Moser into the mat with a cross-face after only 1:29 of the first period...