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...point, some of the 100 test subjects already boast of significantly improved health. But researchers are wary of drawing any conclusions before discovering whether the potential benefits outweigh the risks of heightened cholesterol levels and cardiovascular disease. Whatever the results, insists Dr. Diane Meier, associate professor of geriatrics at Mount Sinai Medical Center in New York City, "the view that nothing can be done is inappropriate. There is no place for therapeutic nihilism...
...latest compounds are aimed at exact targets in the brain. "When you wanted to develop a new drug, you used to copy an old one that worked, add a little twist to the molecule and test it out on patients," explains Dr. Kenneth Davis, chairman of psychiatry at Mount Sinai School of Medicine in New York City. "If you were lucky, you got a drug that worked as well as the old one but had fewer side effects. Now we can be very specific and say, 'Let's go after the D3 receptor or the D4 receptor...
...pharmaceutical firm Sandoz, Clozaril was aimed at patients who did not benefit from other drugs. While traditional antipsychotic drugs such as chlorpromazine (Thorazine) and haloperidol (Haldol) work by blocking dopamine receptors, Clozaril appears to bind to serotonin receptors as well. "It is what we call a dirty drug," says Mount Sinai's Davis. "It probably binds to a whole bunch of receptors. We used to think that was a bad thing. Now we think that's maybe a good thing." Perhaps because of its affinity for serotonin receptors, Clozaril is largely free of the Parkinsonian side effects (the "Thorazine shuffle...
...cloudy morning last December, as the white light of winter picked its way across the face of Mount Rainier, William H. Gates III, chairman and chief executive officer of Microsoft Corp., rolled out of bed after a brief night's sleep. There was no time for breakfast. He showered, pulled on his customary slacks, open-necked shirt and sweater, and climbed into his Lexus for the 20-minute drive from his suburban Bellevue, Washington, home to the Seattle convention center...
...satellite captures a powerful, poetic portrait of Hurricane Fran It's one of nature's dark ironies that the most horrific expressions of its power are also the most beautiful. Think Mount St. Helens or a Pacific tsunami. Add to these Hurricane Fran, pinwheeling toward the U.S. last Wednesday...