Word: multi-drug
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First, the current treatment regimen requires patients take a cocktail of four drugs, all nearly half a century old, for at least six months. The logistical and financial hurdles associated with paying for and completing treatment, however, virtually guarantee noncompliance and relapse. Second, in a cascade effect, noncompliance selects for drug-resistant strains of the mutated pathogen, precipitating the rise of multi-drug resistant and extremely drug-resistant tuberculosis. Treatment for drug-resistant TB with second-line drugs is astronomically more expensive, more time-intensive, and associated with more toxic side effects. Third, the rise of TB and human immunodeficiency...
...We’re trying to ask how the use of multi-drug treatments impacts the evolution of resistance,” Kishony said...
...more recently, in 2000, the Gates Foundation gave a five-year, $45 million grant to a Harvard Medical School program aimed at battling multi-drug resistant tuberculosis in Peru...
...becoming more common, according to Cohen, Currently, diagnosis of TB does not sufficiently distinguish multi-drug resistant TB infection from other infections, resulting in treatment of isoniazid-immune TB with isoniazid, Murray said. Unless changed, such use of isoniazid preventive therapy “would rapidly accelerate the drug resistance of TB,” Murray said. While isoniazid saves lives, Murray said, this form of preventative therapy should be used selectively. Health officials should implement measures to diagnose multi-drug resistant TB and treat it separately, Cohen said. But such procedures would be expensive and, according to Murray, measures...
...enhance its public image by matching donations to disaster relief materially disadvantages these efforts—efforts which, ultimately, have more value than relief itself. It is true that $25.9 billion could rescue much of Niger from famine. It could buy crates of second line antibiotics to combat multi-drug resistant tuberculosis worldwide. Harvard’s endowment could even de-mine the Korean border eight times over. In doing so, however, Harvard would forfeit the money necessary to cultivate the University’s unique contributions to education and research. The University would merely be accomplishing something that every...