Word: mutant
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Dates: during 1990-1999
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...form of mutant mouse engineered by Tsai and her colleagues at HMS is starting to unravel what is considered to be one of the greatest enigmas in biology...
...mistakenly touted as a kind of "morning after" treatment that allows people to relax their guard and engage in risky sexual behavior. By desensitizing the virus to medications, it could jeopardize a patient's ability to respond to future treatments. Worse yet, it could inadvertently create a mutant strain of virus resistant to all currently available drugs--a kind of super HIV--that could lead to a second, even more devastating AIDS epidemic...
...mystery indeed is solved, the benefits could be enormous. Schellenberg suspects that the same helicase deficit that accelerates senescence in Werner's sufferers might, in a more measured form, cause aging in others. To prove this, he will create a strain of mouse that carries a mutant helicase gene so that he can learn how the enzyme works, and more important, how it can be manipulated. Depending upon what Schellenberg learns from these mice, it might be possible to sidestep genetics and simply use helicase boosters to slow aging in both Werner's patients and healthy people...
...implications for both gene and drug therapy. "What these patients apparently show is that those genes are not necessary for a person's health," says Wong-Staal. "If it's dispensable for the person but not for the virus, then it's a terrific finding. You could create a mutant copy of CKR-5 or inhibit its expression or use chemicals to inactivate...
BOSTON, Mass.: Mice are genetically programmed to take care of their young, according to a study reported in the journal Cell. When scientists at the Children's Hospital in Boston bred a mutant mouse lacking the so-called motherhood gene, the mother ignored her babies after delivering them, preferring to curl up by herself in the corner of the cage. Without the mother to keep them warm, the babies soon died. The gene, known as fosB, is probably activated by the sight and smell of baby mice and sets off a host of other chemical and behavioral reactions. Mouse mothers...