Word: mutant
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Friday, Sep. 30—Sunday, Oct. 2. Mutant Action: The Films of Alex de la Iglesia. Rare U.S. screenings Alex de la Iglesia’s best films—several of which are produced by Pedro Almodovar—an unknown, but virtuosic, European director whose dark comedies (such as last year’s “El Crimen Perfecto”) transcend genre and defy social convention. Brattle Theater. $9. Tickets available at theater or www.brattlefilm.org...
...Yuan could establish a concrete link between mutant proteins and neurodegenerative diseases, she said, medicine might one day be able to remove these proteins from young people at risk...
According to Yi, Yuan’s new project is based on a related model previously indicating that a mutant protein was involved in age-dependent hearing loss...
...will be screening through a large library of chemicals that would promote normal protein at the expense of mutant protein,” he said...
Yuan is perhaps best known for research showing that the abnormal repetition of a protein called polyglutamine in cells led to an overactivation of the enzyme caspase-8—which is critically involved in apoptosis. These results suggested that the mutant protein helped accelerate cell death and degeneration in neural diseases...