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...mystery indeed is solved, the benefits could be enormous. Schellenberg suspects that the same helicase deficit that accelerates senescence in Werner's sufferers might, in a more measured form, cause aging in others. To prove this, he will create a strain of mouse that carries a mutant helicase gene so that he can learn how the enzyme works, and more important, how it can be manipulated. Depending upon what Schellenberg learns from these mice, it might be possible to sidestep genetics and simply use helicase boosters to slow aging in both Werner's patients and healthy people...

Author: /time Magazine | Title: CAN WE STAY YOUNG? | 11/25/1996 | See Source »

...implications for both gene and drug therapy. "What these patients apparently show is that those genes are not necessary for a person's health," says Wong-Staal. "If it's dispensable for the person but not for the virus, then it's a terrific finding. You could create a mutant copy of CKR-5 or inhibit its expression or use chemicals to inactivate...

Author: /time Magazine | Title: AIDS: THE EXORCISTS | 9/18/1996 | See Source »

BOSTON, Mass.: Mice are genetically programmed to take care of their young, according to a study reported in the journal Cell. When scientists at the Children's Hospital in Boston bred a mutant mouse lacking the so-called motherhood gene, the mother ignored her babies after delivering them, preferring to curl up by herself in the corner of the cage. Without the mother to keep them warm, the babies soon died. The gene, known as fosB, is probably activated by the sight and smell of baby mice and sets off a host of other chemical and behavioral reactions. Mouse mothers...

Author: /time Magazine | Title: Mom Always Loved You Best | 7/27/1996 | See Source »

BOSTON, Mass.: Mice are genetically programmed to take care of their young, according to a study reported in the journal Cell. When scientists at the Children's Hospital in Boston bred a mutant mouse lacking the so-called motherhood gene, the mother ignored her babies after delivering them, preferring to curl up by herself in the corner of the cage. Without the mother to keep them warm, the babies soon died. The gene, known as fosB, is probably activated by the sight and smell of baby mice and sets off a host of other chemical and behavioral reactions. Mouse mothers...

Author: /time Magazine | Title: Mom Always Loved You Best | 7/26/1996 | See Source »

...wanted. It's like living in a small town and then moving to New York City. You thought all your life that your old town was the world and that the kid who lived on the corner of the street and had a pierced ear was some breed of mutant. Then you go to New York City and realize the true meaning of perforation--and how you'd like to sit down with that kid now and talk about normal things again...

Author: By Victor Chen, | Title: What It Means to Be American | 7/23/1996 | See Source »

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