Word: mutants
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Dates: during 2000-2009
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...Professor Yuan] is trying to connect two different fields, aging and neurodegenerative diseases,” said Caroline H. Yi, a graduate student at Yuan’s laboratory. “Her hypothesis is that the aging process is somehow promoting the toxicity of mutant proteins in neurodegenerative diseases...
According to Yi, Yuan’s new project is based on a related model previously indicating that a mutant protein was involved in age-dependent hearing loss...
...will be screening through a large library of chemicals that would promote normal protein at the expense of mutant protein,” he said...
Yuan is perhaps best known for research showing that the abnormal repetition of a protein called polyglutamine in cells led to an overactivation of the enzyme caspase-8—which is critically involved in apoptosis. These results suggested that the mutant protein helped accelerate cell death and degeneration in neural diseases...
Like Rocky, the hunky mutant concocted by Mad Scientist Dr. Frank-N-Furter, The Rocky Horror Picture Show is a creature spawned in countercultural obscurity and now deemed truly beautiful to behold. The film bombed so ignominiously in its 1975 American premiere that the distributor, 20th Century-Fox, was ready to give it up for dead. Ten years after, this polysexual rock-'n'-roll travesty has earned over $60 million at midnight box offices. But R.H.P.S. is more than a sleeper hit for insomniacs. It is a cross-generational phenomenon, an evocation of '50s monster movies wrapped in the anything...