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...form of mutant mouse engineered by Tsai and her colleagues at HMS is starting to unravel what is considered to be one of the greatest enigmas in biology...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

...elucidate the gene's effects, Tsai used a recently-developed technique which allows researchers to selectively create "knockout mice"--mutant mice who are lacking in a specific gene. The researchers can then study the effect the loss has on the mutants by recovering the excited gene for study...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

...mutant mice, the corpus callosum--the bundle of fibers which connects the two hemispheres of the brain--was almost non-existent. Additionally, the general pattern of connections in the rest of the cortex seemed to be highly altered...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

...This mutant provides the first evidence that such a signaling pathway exists," Tsai says...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

...mistakenly touted as a kind of "morning after" treatment that allows people to relax their guard and engage in risky sexual behavior. By desensitizing the virus to medications, it could jeopardize a patient's ability to respond to future treatments. Worse yet, it could inadvertently create a mutant strain of virus resistant to all currently available drugs--a kind of super HIV--that could lead to a second, even more devastating AIDS epidemic...

Author: /time Magazine | Title: DR. DAVID HO: THE DISEASE DETECTIVE | 12/30/1996 | See Source »

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