Word: myeloma
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...details were fragmentary, but the results looked promising. Of 16 patients with breast cancer that had metastasized (spread to other parts of the body), seven cases showed noticeable improvement, five of them enough to be classified as partial remissions. Tumors shrank substantially in three of eleven patients with multiple myeloma, a cancer of the bone marrow. Though it is too early in the treatment of patients with lymphoma (a cancer of the lymph system) or melanoma (skin cancer) to assess the effect of the drug, the attending doctors see encouraging signs. Discussing the early results, Frank Rauscher, head of research...
...flew to Sweden to observe Strander's work, and soon became a convert. Says he: "There was no question. He was having good results." Back home, Gutterman obtained money from a private foundation to buy enough Finnish IF to try it on 38 patients with advanced breast cancer, multiple myeloma or lymphoma. Again the results were encouraging. Seven of 17 breast cancer patients had positive results, as did six of ten with myeloma and six of eleven with lymphoma...
...victim is in remission after 15 months of interferon therapy. Gutterman also reports a wide range of sensitivity among patients, some showing improvement within 48 to 72 hours and a 50% reduction in the size of their tumors within three to four weeks after IF therapy. One patient with myeloma received interferon for three months with no apparent effect. But one month after the treatment ended, his tumor began to shrink. Presumably IF had had a delayed effect...
Today's IF test subjects must meet highly specific requirements, called "protocols." For example, eligible participants might include 1) breast-cancer patients, but only if surgery and radiotherapy have failed to halt the disease, 2) myeloma victims, and 3) patients with types of lymphoma that do not respond well to conventional treatment. The choice is also usually made from among patients already under treatment at a center where interferon is being tested...
...Arizona team began applying anticancer drugs to cells taken from tumors and then culturing the cells in order to, in their words, "determine whether there are correlations between what is observed in the petri dish and in the patient." Tumor cells taken from nine people with myeloma, a bone marrow malignancy, and nine with ovarian cancer were exposed to varying concentrations of several anticancer drugs, then cultured in petri dishes. The researchers compared the effects of the drugs on the cultured cells with the patients' responses to the same drugs. In all but one case, the effects matched...