Word: myoglobin
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...hospital, our medical people pulled out all the stops. Cardiology came in because his heart was stuttering. Renal was called because Sandy's muscles - ripped around his broken hip, and squashed by his body weight on the hard floor - were producing myoglobin, which, along with dehydration and low blood pressure, was poisoning his kidneys. In the hospitals where I trained, this case would have been a "save" - a great grand rounds case. But here, especially with no family hovering, the only human audience was the crew taking care...
...part to a hiatus for military work in World War II, he was still pursuing his Ph.D. on the X-ray diffraction of hemoglobin, the iron-carrying protein in blood. Watson, meanwhile, had gone to Cambridge to use X-ray diffraction to understand the structure of another protein, myoglobin...
...only two proteins have yielded to X-ray analysis of this type--hemoglobin and myoglobin. The latter, which carries oxygen in the muscles, was the first whose structure was determined. Kendrew's model shows it to be a three-dimensional "lace-work of fabulous complexity," devoid of any regular or simplifying features, apart from the alpha-helix...
Perutz' X-ray studies of hemoglobin have not yet reached the same high degree of resolution and show far less detail than Kendrew's X-ray analysis of myoglobin, which Perutz says "opened a rich mine of stereochemical information about protein structure...
...they reveal that hemoglobin contains four polypeptide chains of roughly equal length, identical in pairs, and structurally complementary. Both hemoglobin and myoglobin have polypeptide chain folds; this characteristic tertiary structure may be fully determined by their amino acid sequence...