Word: naproxen
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Dates: during 2000-2009
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...Pfizer's move is a dramatic one, but it's also an important one-and not just for Big Pharma's balance sheets. In the wake of the Vioxx withdrawal, many arthritis sufferers have turned to drugs in the ibuprofen and naproxen families, such as Advil and Aleve. But earlier this year the Food and Drug Administration (FDA) announced that those drugs may also carry cardiovascular risks; in any event, for some people they just don't pack the same pain-relieving punch. Others patients are relying on oxycontin and morphine-based medications, which may not endanger the cardiovascular system...
...people in the new study, who will be drawn from the U.S., Canada, Eastern Europe, Australia and South America, will be randomly assigned a regimen of either Celebrex, ibuprofen or naproxen. They will also take aspirin, cholesterol-lowering drugs and other medications appropriate for heart patients, as well as a drug to prevent stomach bleeding, which all three of the painkillers may cause. The four-year study should be sufficient time to reveal what risk, if any, the cox-2s pose, but it could end sooner if one of the medications reveals itself as just too dangerous...
Some ulcers, however, can't be pinned on H. pylori. Instead, they are caused by prescription and over-the-counter anti-inflammatory drugs, such as ibuprofen, aspirin and naproxen, that interfere with the body's mechanism for protecting the stomach lining. The ulcers are particularly common among the elderly, who take a lot of those medicines. Healing begins as soon as you stop taking the drugs...
Aleve may yet get a clean bill of health. The National Institutes of Health issued its warning on naproxen based on a study of long-term use that hasn't been completely analyzed--and is contradicted by other findings. But the latest rash of drug scares serves as a timely reminder that even the safest FDA-approved medications can have side effects--some of them serious. (Don't think you're in the clear if you take herbals and other alternative remedies. Much less is known about their safety...
...NAPROXEN...