Word: naproxen
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Mylan's pricing strategy was designed to get the company out of a double whammy. At the pharmacy counter, brutal price competition for drugs such as captopril, a hypertension remedy, and naproxen, an antiarthritis drug, has hurt margins. At the factory, the company is facing an escalating legal and regulatory campaign waged by brand-name pharmaceutical companies such as American Home Products and Merck to extend patents on their drugs or prevent others from manufacturing them. "Generics are caught in a squeeze, which is why only half the 24 publicly traded companies in the industry are profitable," says Jerry Treppel...
Some days the arthritis pain would get so bad that Sylvia Zebroski, 51, of Stamford, Conn., couldn't sleep. Aspirin worked for a while, but then she developed stabbing pains in her stomach. She switched to naproxen, which, like aspirin, is a so-called nonsteroidal anti-inflammatory drug, or NSAID. Same story. "I took myself off naproxen and went to my doctor in tears," she recalls. He put her on a new experimental drug, and this time, no arthritis pain--and no stomach pain. Says Zebroski: "It's made all the difference in the world...
...Anti-inflammatories can damage the lining of the stomach. Now, however, ARTHRITIS patients who use anti-inflammatories like naproxen, ketoprofen and ibuprofen can halve their chances of getting an ulcer if they also take a stomach-acid-reducing drug called famotidine...
Tylenol is being challenged by new over-the-counter drugs such as naproxen (brand name: Aleve) and ketoprofen (brand name: Orudis), as well as aspirin. Advil, which is ibuprofen, holds a 12.9% market share and has sold more than 48 billion doses since it became nonprescription in 1984. It contributes some $350 million annually to American Home Products' coffers...
...take 21 days' worth of pills for 24 hours' worth of relief. And then there are the dangerous side effects" (increased blood pressure, a greater risk of stroke and cardiovascular disease). Aspirin is helpful against mild pain. Most favored today are three drugs used against arthritis: ibuprofen, naproxen sodium and mefenamic acid...