Word: nausea
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Dates: during 2000-2009
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...degrees Fahrenheit at the time of his death." Maria de Jesus Bautista had worked in the fields all her life and had never been sick from the heat, but in July 2008 while picking grapes in Riverside County in 110 degrees she complained to her sister of a "headache, nausea and cold sweats." According to the lawsuit, "She continued to work the rest of the day because her employer did not provide any shade and she felt pressured to keep pace with her co-workers. Over the next two weeks, her headache persisted, she became disoriented and was unable...
...places to treat morning sickness. In the new study, the largest one of maternal metoclopramide use to date, involving nearly 3,500 babies born between 1998 and 2007 in a region in southern Israel, the rate of congenital birth defects in babies born to mothers who used the anti-nausea drug was about the same as that in babies whose mothers had not (5.3% vs. 4.9%). What's more, the length of time pregnant women used the drug appeared to not affect the rate of abnormalities in their babies: 4.9% of women who took metoclopramide for up to one week...
Until now, there have been only about half a dozen studies looking at metoclopramide as a treatment for morning sickness. Even taken together, these studies include only about 500 babies. Because of the paucity of data, most doctors have prescribed the drug for nausea infrequently and only as a last resort - for instance, in cases where nausea and vomiting are so severe that a woman cannot function. Most mothers-to-be in the U.S. are given antihistamines instead, which help calm queasiness with few lasting effects on the fetus; the only downside for moms is side effects like drowsiness. (Read...
...before that can happen, he warns, more studies need to be done on how well metoclopramide actually controls nausea. At the moment, the drug, which calms digestive activity by slowing the contraction of intestinal muscles, is approved by the FDA only for the treatment of heartburn and other intestinal disorders. The drug's mechanism is believed to combat nausea by relieving the spasms that prompt queasiness. "What happens when people vomit or feel nauseous is that everything is stopped up," says Koren. "Metoclopramide helps move things forward and does not cause sedation like antihistamines...
Only additional studies can determine whether metoclopramide or an antihistamine is the better treatment for the nausea that accompanies hormonal changes in pregnancy. The new study should help those future studies along, since it now appears that exposing babies to metoclopramide does not put them at increased risk of developmental abnormalities. "These findings may change practice and help people to be less hesitant to use the drug," says Niebyl...