Word: neklason
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...believe the genetic change either originated with George Fry or his wife, or that it began with a Fry in England, who died before passing it further.) "These mutations all start somewhere, most of them are neutral, some are beneficial, occasionally you get one that is harmful," says Deb Neklason, lead researcher of the study, published this month in the journal Clinical Gastroenterology and Hepatology...
...researchers studied two large families, one in Utah and the other in New York, both carrying the same genetic mutation. It was a true "Aha!" moment, says Neklason, when she linked the two families to a common ancestor. "I tried to connect them years ago anticipating that they would come together in the 1700s," she says. "I was amazed that they went further back, and thrilled with the impact of this finding." There is a 15-generation span between George Fry and his wife and the Fry ancestors today...
...Neklason says that her study underscores the importance of knowing one's family history, being vigilant about health and, if necessary, getting a genetic test. About 5% of colon cancers are known to be hereditary, and another 25% have some familial, or genetic, component that researchers have not yet pinpointed (the majority of colon cancers, however, are linked to environmental and lifestyle factors, such as diet and smoking). If you have had 10 or more polyps, then you should consider genetic testing; if a genetic mutation is identified, your relatives should also be tested. If your family lineage links...
...Neklason and her colleagues are still hunting down other people who have inherited a genetic risk. So far, the researchers have identified 13 other families in the U.S. who have the same genetic fingerprint and founder mutation and are all related. "We think those other 13 families out there link in at some point and we predict that there are hundreds of families out there who carry this genetic risk," says Neklason...
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