Word: neomycin
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Dates: during 1950-1959
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Using U.S. students in Mexico City as willing guinea pigs, Dr. Kean and colleagues tested the value of drugs as preventives. They found that a popular nonprescription item, Entero-Vioform, gave no more protection than an inert (dummy) pill; an antibiotic, neomycin, appeared to give about 40% protection. But before they prescribe free-for-all use of such potent drugs as antibiotics and sulfas, the researchers want to know more about many factors, including viruses, as causes of globetrotters' trots...
Every week U.S. physicians are being bombarded with samples and ads of prefabricated antibiotic combinations-penicillin with novobiocin, neomycin with bacitracin, oleandomycin with tetracycline, and dozens more. In addition, antibiotics are offered in combination with the sulfas or with unrelated items-anti-histamines, hormones, vitamins. Just how good are these package drugs...
...tried hard to tame actinomycin, but none of his chemical tricks seemed to work. After thousands of animals had been killed in his Rutgers University lab, he gave up and began hunting other antibiotics. By 1943, he found the wonder drug, streptomycin. In 1949. he and his assistants produced neomycin (TIME, April 4, 1949). Actinomycin became a half-forgotten curiosity. Dr. Waksman kept only a sample somewhere in the litter on his desk...
...Cortisone is extremely useful in many eye infections because it prevents scarring of the cornea, but it has no power to kill the germs. Now the Upjohn Co. has combined cortisone with the antibiotic neomycin, expects the two-way treatment to be especially valuable in pinkeye...
Researchers at the University of California have found that there are about as many cases of antagonism between the drugs as there are of cooperation. By & large, they report, any two of four antibiotics in Group I-penicillin, streptomycin, bacitracin and neomycin-work well together. Except in rare cases, however, none of these four should be used with an antibiotic from Group II: aureomycin, Chloromycetin, terramycin. And while no great harm may come of combining two antibiotics within Group II, no real advantage can be expected either; the combination simply works like a bigger dose of either drug alone...