Word: neurogeneticist
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...question we still need to resolve," muses neurogeneticist John Hardy of the Mayo Clinic in Jacksonville, Fla., "is, What is the relationship between beta amyloid and tau?" That is why Hardy and others are so excited by the new strain of transgenic mice that scientists are breeding. By crossing mice that develop tangles with mice that develop plaques, they should finally be able to provide scientists with a research tool they've sorely lacked: lab animals that closely approximate the disease in humans...
...stretching back over many generations. After three years of work, they isolated two genetic markers, or molecular signposts, on chromosome 21 that are located close to the still unknown gene responsible for the inherited form of the disease. "The identification of these markers overcomes a major hurdle," says M.G.H. Neurogeneticist James Gusella, who directed the research. "This is the first step toward the identification of the primary cause of the disease." (Gusella has another claim to fame: he headed the group that in 1983 found the long-sought marker for Huntington's disease...
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