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...Detrick. Md. Next week it will become the site of an important experiment. Converted at a cost of $250,000, the facility has been certified by the National Institutes of Health as the nation's first P-4 laboratory, where the riskiest genetic research now permitted by the NIH can be conducted. The lab's initial test will attempt to answer two vital questions: Can recombinant DNA research create dangerous organisms? If so, can they be safely handled in a laboratory...
...first stage of the experiment, NIH'S Malcolm Martin and Wallace Rowe will splice DNA from the polyoma virus (which causes tumors in mice but not in humans) into a specially engineered strain of the common bacteria Escherichia coli. The bacteria will be fed to or injected into mice and hamsters, which will then be examined to determine 1) if the bacteria multiply into progeny that also contain the viral DNA, and 2) if the bacteria-carried viral DNA can cause tumors in the animals...
...experiments will also provide a good test of Building 550, which was designed to prevent material from recombinant DNA work from escaping into the environment. NIH officials are confident that the new lab is even more secure than the Lunar Receiving Laboratory, which was built by NASA at a time when it was still thought that astronauts might bring back dangerous bugs from the moon...
...appropriations sub-committee can reverse the trend away from fundamental research by increasing the allotment for the NIH in the federal budget, or by explicitly stressing basic over applied research in the NIH budget...
...want $100 million more for the National Institute of General Medical Science this year, and also a substantial increase in the NIH budget to create a sufficient increase in project grants," Hoagland said...