Word: nih
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...lead not only in molecular biology but in all scientific accomplishment. In the mid-1950s, the U.S. government rapidly expanded the National Institutes of Health to underwrite and supplement the research of American biomedical scientists, many of whom have made their most important contributions while working in the nih laboratories in Bethesda, Maryland. One result of this strategy: since 1960, more than 50% of the winners of the Nobel Prize for Physiology or Medicine have been Americans...
...without risks. Because it thins the blood, it can also worsen a stroke by causing bleeding into the brain. "You can't know [in advance] which patient will have serious adverse effects," says Dr. John Marler of the National Institute of Neurological Disorders and Stroke, who headed the nih study of TPA. But some specialists believe the risk of bleeding from TPA is greater a couple of hours after the stroke. And they are adamant that the drug should never be used after three hours. Neurologists are now learning the subtle signs by which cat scans can reveal...
Arthur Ullian feels that Reeve has been indispensable to the cause of spinal-cord injuries. "You'd never have got the national focus without him," he says. "You'd never have got the excitement at NIH. Unfortunately, diseases need icons. Chris has been that." Kirshblum of Kessler adds that Reeve has been invaluable as an inspiration to other patients. "When they hear me encourage them, they can think, 'Talk is cheap.' But they can see Chris." Young of N.Y.U. says Reeve is mainly responsible for getting Congress to pay attention to the issue. While noting that promises from politicians...
...Reeve went to Washington to lobby directly for research funds. He met with President Clinton and secured his promise to add $10 million to the National Institutes of Health (NIH) research money; Pennsylvania's Arlen Specter of the Senate subcommittee on Labor, Health and Human Services offered to add $40 million more. Soon after, as the new a.p.a. chairman, he flew to Puerto Rico and helped raise $600,000 at a benefit. Last week he was host of the Paralympics in Atlanta. Next week he addresses the Democratic National Convention with a nonpartisan appeal for research support...
Methylprednisolone is a major advance in the spinal-cord research for which Reeve is now seeking support. An NIH-supported study showed that if MP was given within eight hours of a spinal-cord injury, a patient could save about 20% more neurons than if the drug was not used. For some, this 20% could mean the difference between breathing on their own and having to use a ventilator. Doctors speculate that at high doses, MP no longer acts as a steroid but instead inhibits the breakdown of fats into the dangerous free radicals that are like acid to cell...