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This month, after a painstaking 2 1/2-year investigation, a five-member senior NIMH panel charged that Breuning "knowingly, willfully, and repeatedly engaged in misleading and deceptive practices in reporting results of research." Concluded the panel: "On the basis of all the facts, Dr. Stephen E. Breuning has engaged in serious scientific misconduct." Among other penalties, the NIMH recommended that Breuning be barred for ten years from receiving any contracts or funds from the Department of Health and Human Services. It also referred its findings to the Department of Justice for possible prosecution...
...retarded with powerful antipsychotic drugs, such as haloperidol and chlorpromazine, was being questioned. Breuning's opposition to the overuse of such drugs was shared by other researchers in the field. Even so, some scientists believe Breuning went overboard in discounting the benefits for many severely disturbed patients. Says acting NIMH Director Frank Sullivan: "The retarded are vulnerable. They might have been damaged by false research...
...severity of mentally ill patients' symptoms. "What's wrong with you?" Sprague recalls one of Bruening's co-workers saying. "We get 100% agreement." That idle boast of scientific exactitude -- a virtual impossibility -- persuaded Sprague to look back through his colleague's research and then to contact the NIMH, which had funded both Breuning's and Sprague's work...
...thing characterized Breuning's research, it was perfection," says the NIMH's Sullivan. "Now we know that it was too good to be true." The reports, says Agency Official Lorraine Torres, often included meticulous details for experiments that never took place and descriptions of the training . of individuals working on imaginary projects. One publication Breuning co- authored was an analysis of data on ten mentally retarded young adults, apparently gathered while he was working at the Oakdale Regional Center for Developmental Disabilities, in Lapeer, Mich. Oakdale officials told the NIMH that as far as they knew, the research never took...
...necessarily. Two studies also published in last week's Nature revealed no link between the chromosome 11 site and manic depression in six non-Amish families prone to the disease. Still, these findings do not undermine the important discovery of a genetic basis for the ailment. Instead, observes NIMH Psychiatrist Sevilla Detera-Wadleigh, who led one of the other studies, they suggest that more than one gene may be involved in manic depression...