Word: nimh
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...first part of determining how those genes work is figuring out where they are hiding, and the National Institute of Mental Health is looking hard. Investigators at eight research centers around the country, working under an NIMH grant, are studying the genomes of 500 families with a bipolar history to see what genetic quirks they share. So far, at least 10 of the 46 human chromosomes have shown irregularities that may be linked with the condition. The most interesting is chromosome 22, which has been implicated not only in bipolar disorder but also in schizophrenia and a little-known condition...
...cold sweat. Heartbeats race, and blood pressure rises. That gives scientists something they can control and measure. "You can bring on a sensory stimulus that makes an animal--or human--fearful and study its effects," says Dr. Wayne Drevets of the National Institute of Mental Health (NIMH). "Then you can take the stimulus away and see how the animal calms down...
...that the amygdala is very active in depressed patients, even when they are sleeping. Studies of twins suggest that many of the same genes could be involved. "There's a lot of overlap," says Dr. Dennis Charney, chief of the research program for mood and anxiety disorders at the NIMH. "Anxiety and depression have a similar underlying biology, and the genetics may be such that anxiety surfaces early in life and depression later on." Still, no one can say for sure...
...added, it was “unusual” for people to “talk back to you” at NIMH...
...described his time at NIMH as a “golden age” in terms of congressional support and potential for accomplishment, but when the Harvard job offer came, Hyman said, he was ready to leave the “hierarchical” NIMH...