Word: notch1
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...study, Aster and his co-workers have discovered a common mutation in a gene called NOTCH1 in 55 to 60 percent of all T-cell acute lymphocytic leukemia patients...
According to Aster, normal NOTCH1 gene activity is essential for T-cells, which defend the body against disease, to mature. The NOTCH1 gene is mediated by a critical molecule called gamma secretase...
...patients with T-cell acute lymphocytic leukemia, the NOTCH1 gene is mutated and gamma secretase keeps the gene turned on, leading to T-cell overproduction and eventually leukemia...
...meantime, scientists are studying the NOTCH1 gene and its role in leukemia...
...want to understand the basic events in NOTCH1 signalling,” said Stephen Blacklow, associate professor of pathology at HMS and co-author of the study. “Hopefully this will lead to the discovery of broad-based mutations underlying all cancers...
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