Word: novobiocin
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...with a sulfa: the FDA believes firmly that these fixed-dosage forms are likely to give a patient either too much or too little of one drug or the other. But many physicians have gone on prescribing them. The most noted example was Upjohn's Panalba (tetracycline with novobiocin), which is now off the market. Soon to follow, if FDA has its way: Squibb's Mysteclin-F (tetracycline with amphotericin B) and Roerig's Signemycin line (tetracycline with troleandeomycin...
...cases in which FDA has taken decisive action, it has run into strong opposition. The agency is trying to remove from the market 1) a combination of two antibiotics, tetracycline and novobiocin, marketed by the Upjohn Co. as Panalba, and 2) a combination of tetracycline with an antifungal agent, sold as Mysteclin-F (E. R. Squibb & Sons), Declostatin (Lederle Laboratories) and Tetrastatin (J. B. Roerig division of Chas. Pfizer & Co. Inc.). Upjohn has already taken its case to the courts, and the other firms may do so as well. Both drugs are widely prescribed items, ringing up tens of millions...
...seven wards they put an outright ban on all the most cherished antibiotics (penicillin, streptomycin, three tetracyclines, chloramphenicol, erythromycin and novobiocin) unless the doctors could show that one of these drugs was unquestionably the best for the patient's disease. Then they had to give their first-choice antibiotic in combination with a second, to cut down the microbes' chance to develop resistance. Penicillin, as the drug previously most abused, was put under special restrictions: on some wards it could not be given at all, and when used, it had to be injected on a side ward...
Every week U.S. physicians are being bombarded with samples and ads of prefabricated antibiotic combinations-penicillin with novobiocin, neomycin with bacitracin, oleandomycin with tetracycline, and dozens more. In addition, antibiotics are offered in combination with the sulfas or with unrelated items-anti-histamines, hormones, vitamins. Just how good are these package drugs...
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