Word: nuechterlein
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Dates: during 1990-1999
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...term, that meant Aller would get medicine to make him well. But the long-range realities were harrowing. If he got well, the experiment would follow Greg as medication was withdrawn. If he then became ill, he could fall into the worst stages of psychotic relapse. Last March, Keith Nuechterlein, the project's director, sent a letter to his patients stating that among the findings of the experiment, three-quarters of the people who have been off medication "will experience a return of significant symptoms within a year." In 1990 Greg was among those who relapsed -- and, as his condition...
Greg's parents were ecstatic with his progress. They were, however, wary of Phase 2. They talked to Nuechterlein and Greg's caseworker, Joseph Tietz, a graduate student. "We knew when Greg went into the program that they would take him off medication at a certain point," says Gloria Aller. "They explained to us that this was to test whether he really needed it for the long run." The scientists noted that antipsychotic drugs have powerful side effects, and they were trying to identify patients who might be able to stay off medication and avoid them. Among the drug...
...parents understood that Phase 2 dealt with identifying schizophrenia patients who could be treated without continuing doses of Prolixin, the Allers last year came across a document they thought suggested that the doctors had a somewhat different agenda. In a 1988 paper, based on data from UCLA's experiment, Nuechterlein and one of his graduate students reported on early, or "prodromal," signs of schizophrenic relapse. They noted that their study differed from earlier studies in following research subjects in relapse "to the severe or extremely severe level." In contrast to other studies, the paper claimed, this study was not constrained...
...symptoms were "not severe enough" to remedicate him. Tietz asked Bob to write him a letter. The Allers did, saying, "Our understanding was that there was a safety net of medication available whenever Greg exhibited serious symptoms that impaired everyday behavior." The Allers then met with Nuechterlein and Tietz, and they say they were told Greg's behavior could not yet be called a relapse. It was merely a mood fluctuation and temporary...
...bedroom. The Allers began barricading their bedroom door at night. Bob and Greg argued at one point, and Greg kicked his father and threatened to kill him. On Jan. 23 he packed his things and moved out. He was flunking out of school. Two days later, he saw Nuechterlein's partner, Dr. Michael Gitlin, who noted, "Moved out from parents. Says no symptoms present. Finishing the semester...