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...sample of 3,131 cancer specimens of 26 cancer types, the group identified 158 regions of focal somatic copy number alterations (SCNAs) that were frequently altered across several cancer types. Somatic copy number alterations occur when there are abnormal numbers of chromosomes within a tumor’s genome, Mermel said...
Although the exact role of SCNAs is still unclear, the researchers found that a large number of SCNAs identified in individual cancer types are present over several cancers of different origin. The common SCNAs may act as important markers in the diagnosis and treatment of cancer, according to Rameen Beroukhim, a clinical fellow in oncology at Harvard-affiliate Dana-Farber Cancer Institute...
...Each cancer type obviously has a very complicated copy number profile,” Beroukhim said. “Two cancer types individually don’t look that similar, but we found that over such a large number of samples, copy number profiles looked more similar than different...
Before entering the nanofabrication facility at SEAS to coat the micro-particles in gold in her routine procedure, Sridhar must undergo a number of security measures: she has her iris scanned, and she swathes herself in a complete outfit that includes booties—which go on first, she said—and a white suit...
...current crop of Harlem politicians know that measuring up to their predecessors' accomplishments is impossible. "They are absolutely historic figures," says New York state assemblyman Keith Wright, who represents the district. "Without Percy, Charlie, Basil and Dinkins, you probably wouldn't have this number of [politicians] in Brooklyn, in the Bronx, in Queens. They're pioneers." But Wright acknowledges that the power they accumulated is now flowing elsewhere - to the outer boroughs of New York City and to cities like Chicago, President Barack Obama's adopted hometown...