Word: nun
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...debate. As laboratory scientists and clinicians are quick to point out, cause and effect are notoriously difficult to tease out of population studies like this one, and exactly what the emotion-Alzheimer's link means has yet to be established. But even hard-nosed lab scientists admit that the Nun Study has helped sharpen the focus of their research. The study has impressed the National Institutes of Health enough that it has provided $5 million in funding over the past decade and a half. "It is," says Dr. Richard Suzman, director of the National Institute on Aging, "a very innovative...
Chicken studies wouldn't cut it with the Minnesota administration though, so Snowdon was interested when a graduate student, an ex-nun, told him about the aging sisters at her former order, living out their retirement in a convent just two hours away. He was already familiar with the advantages of studying religious groups, whose relatively uniform backgrounds mean fewer variations in lifestyle to confound the data. An order of nuns whose economic status, health care and living conditions were especially uniform would be an excellent starting place for an epidemiological study of the aging process. So he went...
...epidemiologist could not have designed a better way to evaluate them across time. "For many years," says the National Institute's Suzman, "we had an inadequate sense of how connected late-life health, function and cognition were to early life. But in the past decade, spurred by the Nun Study, there is a growing appreciation for that connectedness...
...took their vows in 1925 to both survive and remain mentally intact. "But I thought if science could learn something from this program, then I was glad to be a part of it." In 1991, the first participant, a resident of Good Counsel Hill convent, died, and the Nun Study received its first brain...
Another crucial finding from the Nun Study came in 1997, by which time Snowdon had accumulated some 100 brains for analysis. He and neurologist Dr. William Markesbery, director of the Alzheimer's Disease Research Center at the University of Kentucky, were intrigued by an idea advanced by other researchers that strokes and other brain trauma might contribute to the dementia of Alzheimer's disease. Selecting only the brains of sisters who had earned a bachelor's degree--to eliminate any differences attributable to education--they found that among nuns with physical evidence of Alzheimer's in the brain, those...