Word: nydrazid
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...hydrazide of isonicotinic acid, marketed under such names as Rimifon, Nydrazid, Pyricidin, Dinacrin. A related drug is trade-named Marsilid...
...will take six months for doctors to render a confident verdict on Rimifon, Marsilid and Nydrazid. Meanwhile, there is a sobering lesson in the history of anti-TB drugs: dozens have come and all but one "wonder drug" (streptomycin) have gone, but TB remains...
With the limited lab facilities of a city hospital, the doctors at Sea View were trying to evaluate the medical progress of their patients when Squibb & Sons gave their Nydrazid to doctors at New York Hospital. There, though patients with advanced TB were scarce, the lab facilities were enormous. Dr. Walsh McDermott began elaborate biochemical tests on Nydrazid and soon made an important discovery: although it is swallowed as a pill (smaller than an aspirin tablet), the substance soon appears in the spinal fluid in "beautiful concentration." This meant that it might be extremely useful for tuberculous meningitis. Other tests...
...Patient Navajo. Another shipment of Nydrazid was sent to Tuba City, where Dr. Charles Clark found, among the unhappy Navajos, all too many cases of both meningeal and miliary tuberculosis. A 17-year-old girl (a miliary case), admitted with a fever of 103° and so weak that she could not walk alone, was fever free within a week and soon coughed no more sputum. Now she is up & around...
...Year's Eve Dr. Elmer Sev-ringhaus of Hoffmann-La Roche dropped in to see Dr. McDermott of New York Hospital and tell him about Rimifon. It was soon clear that Rimifon was chemically the same as Nydrazid, and a week later Squibb and Hoffmann-La Roche got together to plan further testing of the drug and arrange a request to the Food & Drug Administration to have it released for general use by physicians. That release cannot be given until May or June; by then, both companies will be ready to market the drug in wholesale lots...
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