Word: nyhan
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Dates: during 1960-1969
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...that something was wrong with the patients' enzyme systems. But what? Although it was easy to show that victims had an excess of uric acid in their blood, the metabolic pathways by which it got there remained hidden in the biochemical jungle. Then in Baltimore, Pediatrician William L. Nyhan Jr. and Dr. Michael Lesch saw two retarded brothers with the palsy and biting symptoms. It has since been learned that a substance was missing from their blood: an enzyme forbiddingly named hypo-xanthine-guanine phosphoribosyltrans-ferase, or PRT in the trade...
...Family. By now, 80 victims of the Lesch-Nyhan syndrome have been identified. Very few have survived beyond puberty; most are in institutions. All are boys, indicating that the enzyme defect is transmitted, like hemophilia, through the mother on an X chromosome, although she appears unaffected. Researchers at the National Institute of Arthritis and Metabolic Diseases checked to see whether the same enzyme deficiency could explain typical adult gout. It does in only a few cases, they reported last week. In one family, two gout victims have only about 1% of the normal PRT; in another family, it is about...
...Williams 42 3 45 3. Woody Spruance 22 21 43 4. Joe Prahl 14 3 22 5. Tink Gunnoe 15 3 18 6. Pete Sieglaff 14 2 16 7. Pete Wood 7 2 19 8. Harris Leroy 5 2 7 9. Mike Bassett 4 2 6 10. Dave Nyhan...
...second quarter was more of the same. The Ells scored three times more (LaMotte's third goal included); the Crimson tallied once. Dave Nyhan, replacing Spruance on attack, picked up the varsity mark...
...first midfield unit will include "Tink" Gunnoe, Pete Sieglaff and Joe Prahl. All three weigh more than 170 lbs. and play a fast-moving, hard-hitting type of game. They will be backed by Pete Wood, Gil Bamford, and Dave Nyhan on the second midfield...