Word: ohio
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Dates: during 1990-1999
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...work is based on the landmark experiment performed in 1990 by NIH Drs. W. French Anderson, Michael Blaese and Kenneth Culver on two Ohio girls, ages 4 and 9. Neither child was producing ADA, an enzyme that rids the bloodstream of harmful metabolic products. The absence of ADA can cause SCID by allowing toxic substances to accumulate and destroy immune-system cells. Both children had been kept alive by weekly injections of PEG-ADA, a costly synthetic enzyme, but neither was in good health...
...first approved gene-therapy trials, the pioneering NIH team extracted immune-system T cells from the Ohio girls, inserted normal ada genes into the cells and reinjected them. As the team had hoped, the T cells began churning out natural ADA, enabling the children's immune systems to function effectively. While that result marked the first successful treatment by gene therapy, it was not a cure; the altered T cells die out after several months, and the little patients must return to the NIH periodically to repeat the procedure...
...latest experiment at the NIH, Blaese administered a drug to one of his two original Ohio patients that coaxed some stem cells out of the bone marrow and into her bloodstream. Extracting blood, he painstakingly separated out the rare stem cells, inserted normal ADA genes into their DNA and injected the cells back into the girl's bloodstream, hoping that they would migrate back to the marrow and take up permanent residence...
...with all the flaws of the day and hardy battlers for their partisan causes. But they were by almost anybody's standards an extraordinary collection of public figures: Georgia's Richard Brevard Russell, Vermont's George Aiken, Missouri's Stuart Symington, Connecticut's Prescott Bush, Montana's Mike Mansfield, Ohio's Bob Taft, Arkansas' Bill Fulbright, Virginia's Harry Byrd...
John Kasich is a personable youngish Republican Congressman from Ohio and the ranking Republican on the House Budget Committee. He's been getting favorable attention lately for an alternative he has produced to President Clinton's budget plan. Pundits note with respect that Kasich's plan is 80 pages long, which is the main fact they seem to have absorbed about it. That, plus Kasich's claim to reduce the deficit by as much as Clinton proposes over five years, only with no tax increase, with half the cuts in defense that Clinton is proposing, and (Look Ma, no hands...