Word: ojima
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Dates: during 1990-1999
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...example, Iwo Ojima, professor of chemistry at the State University of New York at Stonybrook, is working on an analog to taxotere, a compound similar to taxol, known as Baccatin III. Taxotere, another drug with taxol's properties extracted from the leaves of the European and Indian yew trees, is more widely available than taxol and can be produced in greater quantities...
...disadvantage of taxotere, however, is that it also causes the side effects of taxol. Baccatin III, says Ojima, may grant doctors the best of both worlds by eliminating both taxol's scarcity and its side effects...
...reduce those side effects and make a drug that is easier on the patients," says Ojima. "We are working on a structure activity relationship study and focusing on the new baccatin...
Although trials of the drug are still in their early stages, Ojima says some of the baccatin compounds have already been shown to have a greater effect on tumors than taxol. The compound also dissolves better in water, so it may be easier to administer...
With the increased availability of taxol which the work of Jacobsen, Ojima and others might bring, many oncologists are using it to treat patients with ovarian and breast cancer...