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...similarities to earlier summer fare. This is one of two action films this month with mammoth, John Woo-movie-like explosions in parody form; next week's Tropic Thunder is the other. It is also the second movie this week in which a major plot point is an older man's promise to meet with his student girlfriend's parents. (Cf. Elegy, a romantic drama that has nothing else in common with Pineapple Express.) Finally, it's the third picture this summer, and the eighth in the past 14 months, that was produced, written or otherwise perpetrated by Apatow. Take...
...Rogen is Dale Denton, who works as a process server and plays at being the wise older beau to high-school senior Angie (Amber Heard). But his vocation is dope-smoking, which makes his dealer, Saul (James Franco), if not Dale's best friend then surely his most trusted business acquaintance. It's after a visit to Saul for some amazing weed known as Pineapple Express that Dale parks outside the home of his next subpoena victim, Ted Jones (Gary Cole). BLAM! go some guns, SPLAT! goes the body of an Asian man against the second-floor window, and CRUNCH...
...very unclear [how big an effect that could have]. I've seen men who have done horrendous damage to themselves over time with smoking and drinking and who still get to 100 and older - though that's very, very rare. They might have the right combination of some really special genetic variations that we call "longevity enabling genes" - which we're on the mad hunt for. Meanwhile other individuals may do everything right and only make it into their 80s. That may be because they have what we call "disease genes," some genetic variations that are relatively bad for them...
Another area where we see higher death rates among men is among the depressed - especially older men. If they attempt suicide, they are more likely to succeed than women...
...probably attributable to environmental factors - your behaviors and your exposures. Probably only 30% is due to genetics. And that's very, very good news. There's so much we can do. Most of us should be able to get into our late 80s. What's more, to get to older ages, like the centenarians, you are necessarily compressing the time you're sick to the end of your life. It's not a case where the older you get, the sicker you get. It's very much the case that the older you get, the healthier you've been...