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...Kennedy Jr. - the oldest brother - was his ambitious father's namesake, and repository of all his hopes. On Aug. 12, 1944, he was sent on a secret mission so important that it was filmed in a tailing aircraft by the President's son, Colonel Elliott Roosevelt. But the plane he was flying, loaded with 23,000 lb. of an explosive twice as powerful as TNT, exploded in an immense fireball before Joe could bail out. (See a photo gallery of the Kennedy family's intimate moments...
...Kennedy Jr., the oldest of nine children, was the first to die - at 29 - when the plane he was flying on a World War II mission exploded over England...
...Kennedy had a party. He and Vicki invited about 100 people to Hyannis Port. Chemotherapy had taken a toll on Ted's strength, but Barack Obama's electoral victory had invigorated him. His children, stepchildren and many of his nieces and nephews were there. So were several of his oldest friends, men who had attended grammar school, college or law school with Kennedy. Family and friends: the ultimate safety net. (See video of Kennedy from the 2008 Democratic National Convention...
...family's many biographers, Laurence Leamer, marks the hinge in the Kennedy history - where the arc swings from romance to tragedy - as the day when Joe secretly had his oldest daughter, Rosemary, lobotomized in 1941. Her retardation was a blemish that he thought he might carve away. But for the public, the shadow first fell in 1944, when the oldest, and perhaps the most promising, of the Kennedys, Joe Jr., volunteered for a dangerous combat mission in an experimental flying bomb. The plane exploded before he could bail out. (See TIME's complete Ted Kennedy coverage...
Other personal tragedies followed as family members struggled with drug abuse, disease and premature death. His first wife, Joan, suffered three miscarriages, and after their separation, she was repeatedly treated for alcoholism. Two of his children have battled cancer, with his oldest, Ted Jr., losing a leg to the disease at age 12. (See pictures of a Kennedy family album...