Word: oneness
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Slicing the Sex Data"There are millions of women on a drug with no known benefit and risks that are detrimental to their lifestyle - and no one is talking about it. Why?" asks Dr. Rita Redberg, a prominent cardiologist at the University of California, San Francisco...
...One reason may be that the field of gender-based medicine, which takes into account the differences between men and women in the diagnosis and treatment of disease, has been slow to catch on, especially in the pharmaceutical industry. Before the 1990s, women were largely excluded from clinical drug trials - an attempt to protect pregnant women from harm and avoid the potentially confounding effects of women's hormone fluctuations. Since then, as studies have actively recruited women, gender-based research has begun to reveal crucial information about how the development of diseases - such as heart disease, lung cancer and autoimmune...
...Medical Center in Dallas have long argued that statins should be prescribed to women at moderately high risk for heart disease. Grundy says the underrepresentation of women in drug trials does not discount statins' benefit; it results only in a failure to show a statistically significant effect. Grundy was one of the authors of the 2001 national guidelines for lowering cholesterol and the 2004 revisions that greatly expanded the use of statins - and were criticized because of his and other authors' ties to the drug industry...
...lower risk of hard events, including fatal and nonfatal heart attack and stroke. But the only statistically significant benefits for women treated with Crestor involved less extreme end points, like hospitalization for unstable chest pain and arterial revascularization (a category of procedures that includes major surgery). To prevent one event, 36 women would need to take the statin for five years - a modest result, critics...
...Risk Profile, StupidWhy statins fail to show equal benefits for men and women is unclear, but one reason may be that women are simply at lower risk of heart disease than men. You would need a powerful treatment to lower an already low risk. Researchers also don't know why women are more likely than men to suffer side effects from statins and many other drugs but posit that lower body weight and hormonal fluctuations play a role. Biological explanations aside, the larger point is the same: with any treatment, the benefits should outweigh the risks...