Word: onset
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Dates: during 2000-2009
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...start of the Russian Revolution, U.S. Attorney General A. Mitchell Palmer and rising Justice Department star J. Edgar Hoover took on a "red menace" of radicals, anarchists and Bolsheviks. By 1920, the pair had arrested up to 10,000 alleged subversives. (Most cases were thrown out.) With the onset of the Cold War, fears flared anew. Indeed, the term socialized medicine was coined in the late 1940s by critics of President Harry Truman's national health-care plan. From 1945 to 1960, the House Un-American Activities Committee (HUAC)--which was founded in 1938 to hunt down suspected Nazi sympathizers...
...something called rebaudioside A - Reb A for short - the best-tasting component of the stevia leaf, which has a profile very similar to sugar with respect to onset, intensity and duration of sweetness. Both Truvia and PureVia use Reb A as an ingredient, although Truvia's label lists it as "rebiana...
Based on the prevalence of the new genes and variants in the populations studied, the U.K. and French groups speculate that about 20% to 25% of late-onset Alzheimer's can be explained by ApoE; 8% to 12% by clusterin; and another 3% to 5% by CR1 and PICALM...
...involved in helping to clear away the amyloid that forms in the brain; but another variant of the gene may also allow amyloid to form fibrils, the sticky protein arms that further anchor amyloid plaques to nerve cells, much like a spider web ensnares prey. In late-onset Alzheimer's, it's possible that the body cannot balance these two functions of clusterin. "It may be that the difference between a variant of clusterin that protects from Alzheimer's versus one that has a higher risk is the balance between clearing amyloid versus causing it to form more deposits," says...
...tangles that strangle nerve function, the identification of PICALM suggests that some part of the disease may have to do with a breakdown in nerve-cell communication at the junctures. "If you had given people a list of genes and said which ones were involved in late onset Alzheimer's disease, PICALM would have been less likely than the others to be picked," says Goate...