Word: onset
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Dates: during 2000-2009
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...three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups, one in Wales and one in France, who linked the genes to the most common form of the memory disorder, late-onset Alzheimer's - the type that affects patients in their 60s or later and accounts for about 90% of all Alzheimer's cases. The only other gene connected with the condition, apolipoprotein E (ApoE), was identified in 1993; since, researchers have tirelessly hunted for other key genes, knowing that 60% to 80% of the progressive, incurable disease is genetically based...
...three of the four known genes associated with the disease were connected to the rarer, inherited form, which appears in adults as young as 40 or 50. The three additional genes, identified in the new papers, now tip the balance of genetic understanding in favor of the late onset condition that affects a majority of the 5.3 million patients living with the disease in the U.S. (See how to prevent illness...
...move forward without the Gang of Six? From the onset, many Democrats imagined a certain Central Texas boy twisting arms for Medicare and Medicaid. For them this president is all hat and no cattle...
...idea is not necessarily to diagnose Alzheimer's earlier, says Rao. But imaging studies can help to identify those most vulnerable to cognitive decline so they can participate in clinical trials of new drugs designed to postpone or reduce symptoms. "If we can delay the onset of Alzheimer's by five years," he says, "by some estimates we can cut the incidence of Alzheimer's in half. If we can delay the disease by 10 years, we could almost eliminate it because people would die from other conditions first...
Quitting khat would double the amount of household water available, says Klingler, but that may only slow the onset of crisis. The hydrologist argues that Yemen needs to revert to consuming only as much water as it collects from rains - and to import most of its food from abroad...