Word: orals
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Dates: during 1960-1969
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Food and Drug Administration announced approval of three more oral contraceptives. But with sales of the pills increasing steadily around the world, many questions arise. Just what are the pills? How do they work? Are they certain? Are they safe? What are the disadvantages and discomforts of using them? How long can a woman go on taking them? Could they cause cancer or deform babies in the womb? MEDICINE reports and analyzes the answers and concludes that, in nearly every case, they are reassuring...
Last week, with newly announced approval by the Food and Drug Administration of three more oral contraceptives, American women and their doctors had a total of six to choose from...
Split Schedule. All the oral contraceptives so far approved by FDA contain, in addition to their principal ingredient of the synthetic, progestin, a minute amount of another synthetic hormone, estrogen. This fulfills some of the roles of the estrogen that a woman normally secretes generously during the first part of her menstrual cycle, and it serves to prevent spotting or break-through bleeding in the middle part of the cycle...
Soon, the oral-contraceptive market will be crammed with pills from more manufacturers, some of them to be taken on a divided schedule called "sequential therapy." This system requires taking an estrogen pill for 16 days, then a progestin pill for five days. Its proponents claim that it comes closer to the natural physiological hormone cycle. Mead, Johnson & Co. already has an application before FDA asking approval of sequential-therapy pills compounded of ingredients bought from British Drug Houses, Ltd. And Indianapolis' Eli Lilly & Co., working with Syntex, is on the same tack. Michigan's Upjohn...
Doty said that the committee reached an "oral consensus" about five weeks ago and that the report is now in the drafting stage...