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...brain, after all, is only another organ, and it operates on the same biochemical principles as the thyroid or the spleen. What we experience as feelings, good or bad, are at the cellular level no more than a complex interaction of chemicals and electrical activity. Depression represents an imbalance in that interaction, one that can kill just as directly as more obviously physical ailments. Each year in the U.S., an estimated 30,000 people commit suicide, with the vast majority of cases attributable to depression. But depression's physical toll goes far beyond the number of people who take their...

Author: /time Magazine | Title: Depression: The Power of Mood | 1/20/2003 | See Source »

That could explain why drugs that improve serotonin chemistry don't always work on depression--and why Parkinson's and depression can feed on each another. Epilepsy, stroke and Alzheimer's, which, like Parkinson's, involve physical alteration of the brain, probably also affect that organ's ability to make or process neurotransmitters--not only serotonin and dopamine but also glutamate and norepinephrine, all of which may be involved in different forms of depression...

Author: /time Magazine | Title: Depression: The Power of Mood | 1/20/2003 | See Source »

...think of Wal-Mart as a huge pipe organ with thousands of stops that executives constantly pull and push. Early on the day after Thanksgiving 2001, one of the busiest shopping days of the year, the system was reporting slow sales of a boxed computer-and-printer combo for which merchandisers had had high hopes. But one location was bucking the trend. A quick call from headquarters determined that the store manager had cut open one of the stacked cartons so shoppers could see they got both machines for one price. Soon a message went to all other stores: open...

Author: /time Magazine | Title: Can Wal-Mart Get Any Bigger? | 1/13/2003 | See Source »

...Claire Watts, Wal-Mart's fashion boss. "Would it kill us to be a little more up to date?" Wal-Mart is also importing ASDA's recruiting philosophy, "Hire for attitude, train for skill." Labor is a particularly ticklish subject at Wal-Mart because unions have been trying to organize its U.S. stores. That effort has been unsuccessful so far, in part because Wal-Mart's wages are competitive with other retailers'. But the two most frequent complaints made by Wal-Mart employees to TIME - low wages and morale-killing store managers - recently factored into a labor case the company...

Author: /time Magazine | Title: Inside The World's Biggest Store | 1/12/2003 | See Source »

...vaccine is made up of the live smallpox virus, it can be extremely dangerous to people whose bodies are not capable of fighting off disease. As many as 60 million Americans with compromised immune systems will not receive the vaccine. People with AIDS, HIV, cancer, who have had organ transplants or a history of eczema could suffer extremely serious side effects from exposure to the virus, including death. Pregnant women and women who are breastfeeding should also not receive the vaccine...

Author: /time Magazine | Title: Smallpox: Your Questions Answered | 12/13/2002 | See Source »

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