Word: orphaned
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...rare there is no profit in making drugs to treat them. A pharmaceutical company's investment, up to $80 million for a new drug, cannot be recouped if only 100,000 people or fewer need the product. Such diseases and their drug treatments therefore are said to be "orphaned." Orphan diseases include cystic fibrosis, a deadly hereditary disorder that affects 40,000 Americans; Tourette's syndrome, a neurological abnormality characterized by tics and involuntary outbursts of swearing (100,000 Americans); Prader-Willi syndrome, a children's ailment that causes huge weight gains and often kills its victims...
...recent years, the plight of orphan-disease victims has begun to capture national attention and stir concern. Beginning in 1980, several dramatic hearings of the House Subcommittee on Health and the Environment raised awareness of the issue with testimony from Marjorie Guthrie, the singer's widow, Actor Jack Klugman, whose TV show Quincy devoted an episode to Tourette's syndrome, and researchers like Van Woert. A study by the committee identified 134 drugs to treat orphan diseases, but found that only 58 were on the market or even under investigation by drug manufacturers. Furthermore, more than two-thirds...
There is a wonderful movie fighting to get out of this $50 million musical. Unfortunately for Producer Ray Stark, the movie is Camille, that transcendent Garbo weepie, which Daddy Warbucks takes his button-eyed orphan to see at a Radio City Music Hall advance screening. (Quite a bit in advance: Annie is set in 1933; Camille was released in 1937.) In an adroit 4½-minute condensation, the tragic story of Marguerite and Armand unfolds, brief and mesmerizingly beautiful. The clip also possesses an innocence, a sweetness of spirit, that this 1982 blockbuster never even tries to capture...
...first anvil hint is dropped in the opening scene: in a dormitory of Miss Hannigan's Dickensian orphanage, the eldest of six orphans jumps from bed to bed-and one galumphing foot lands splat! on the forehead of a younger girl. It's no wonder that when Annie (Aileen Quinn) gets the chance to live with Daddy Warbucks (Albert Finney), she promptly forgets her orphan camaraderie. But then the entire movie is a series of plot strands twisted, then discarded...
...multiply your prayers, I shall not listen Your hands are covered with blood wash, make your selves clean Take your wrongdoing out of my sight Cease to do evil Learn to do good, search for justice help the oppressed, be just to the orphan, plead for the widow." Isaiah...