Word: osteopontin
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Dates: during 1990-1999
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Scientists had already discovered that cancer cells produce mass quantities of osteopontin, but they were mystified as to its function, Cantor says...
Cantor proposed and verified that osteopontin which is secreted by cancer cells behaves similarly, drawing the malignancies to all corners of the body just as T-cell osteopontin draws white blood cells to infections...
About eight years ago, the researchers discovered the gene that cancer cells use to make osteopontin. This advance will help them synthesize the proper peptide to block the osteopontin produced by tumors, Cantor says...
...search for the perfect peptide is complicated by the fact that it must not block the activities of the type of osteopontin produced by immune cells. Cantor says additional snags are that the peptide must not be biologically harmful and must be tested on laboratory animals before human trials...
Cantor says he hopes that his research with osteopontin inhibitors can be used to fight AIDS, but says that is a longshot...