Word: oxygenates
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Dates: during 1990-1999
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...every standard medical and logical, Henry Jackson, lying unconscious in a New Jersey hospital on his 32nd birthday, was finished. Massive internal hemorrhaging had drained him of 90% of his blood. His level of hemoglobin--the vital, oxygen-carrying compound in his red cells--had plummeted from a normal reading of 13 to an ominous 1.7, a number that one of his doctors characterized as "incompatible with survival." A blood transfusion could save him, but his wife, torn between her husband's life and their beliefs as Jehovah's Witnesses--a religious community that prohibits transfusions because of biblical references...
When Jackson was wheeled into the institute, Dr. Aryeh Shander, chief of anesthesiology and critical-care medicine, and his team moved swiftly. First, they essentially paralyzed the patient with drugs to reduce the demand for oxygen by his muscles, brain, lungs and other organs. Next, they gave him high-potency formulations of iron supplements and vitamins, plus "industrial doses" of a blood-building drug, synthetic erythropoietin, that stimulates the bone marrow to produce red blood cells. Finally, intravenous fluids were administered to goad what little circulation he had left...
...majored in Asian languages as an undergraduate, is passionate about anything, it is blood. Not only because it is, as Goethe observed, "a very special juice," the fluid pumped by our hearts through arteries, veins and capillaries, and without which the body's cells would be starved of oxygen and nutrients; nor only because he knows blood transfusions save lives; nor simply because 70% of those transfusions are administered by anesthesiologists...
Erythropoietin is usually the drug of choice for bloodless medicine because of its stimulative effect on red-blood-cell production. Hormones and vitamin B12 are also prescribed to encourage cell production. Doctors may employ a hyperbaric chamber to flood patients' blood with higher concentrations of oxygen so that they can better withstand surgical procedures and low blood levels, while oximetry devices and other noninvasive monitoring equipment keep close watch over oxygen levels...
Other factors make bloodless surgery increasingly attractive. Transfusions can suppress the immune system, for example, leaving a patient open to infection, slower healing and a longer recovery time. "Also, banked blood, after it's cooled and stored, doesn't have the capability of fresh blood to transport oxygen," says Shander. "We're just beginning to understand what it is we do when we give a transfusion." Finally, there is the cost: at around $500 for each transfusion, plus administrative add-ons, the total bill comes to between $1 billion and $2 billion annually, more than enough incentive to consider alternatives...