Word: paines
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...Johns Hopkins University School of Medicine in Baltimore, Md. "Each of us has hisown stack of triggers and his own personal threshold at which the migraine mechanism activates. The higher the trigger level climbs above the threshold, the more fully activated the migraine system--and the more pain...
Researchers are exploring the possibility that migraine sufferers are not just hypersensitive to various triggers but that their brains have lost some of their natural ability to suppress pain signals. To find out more, scientists are studying a part of the brain called the periaqueductal gray matter, which, says Dr. Welch in Kansas City, "switches off the pain response so that you can focus on the fight to survive. It's the reason why if you have a cut that you don't remember getting, it doesn't start to hurt until you actually look...
Each time a migraine occurs, Welch and others have found, the periaqueductal gray matter fills with oxygen, which triggers chemical reactions that deposit iron in that section of the brain. As the iron builds up, the brain's ability to block out pain decreases. That may explain why many migraineurs become more sensitive to pain with each episode...
...calm them down--and that's exactly what the first drug tailored to block an oncoming migraine was designed to do. Approved in the U.S. in 1993, sumatriptan mimics the action of a neurotransmitter called serotonin, which plays many roles in the brain, including regulation of mood and pain. In the case of migraines, the drug prevents nerve endings in the dura from releasing their stimulatory proteins. No proteins, no pain...
...Pain relief isn't the only reason to stop a migraine before it goes too far. When the illness goes untreated, there is some evidence "of a mechanism in the central nervous system that makes traditional medications less useful," says Dr. Michael Moskowitz, a neurologist at Harvard Medical School in Boston. How that resistance develops is the subject of intense investigation...