Word: painful
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Dates: during 1990-1999
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...smart money here is on courses taught by people like Michael Sandel or William Gienapp--acknowledged baseball fans who will feel your pain...
...excitement began with a growing understanding of how rheumatoid arthritis works. Unlike its more common cousin, osteoarthritis, which causes pain in more than 20 million mostly older Americans through simple deterioration of joint cartilage, rheumatoid arthritis is a complex disease involving an immune system gone awry...
...Kansas City, Mo., firm Hoechst Marion Roussel, stops white cells from reproducing. Enbrel, a genetically engineered medication from Seattle-based Immunex, works by sopping up a tumor-killing cytokine called tumor necrosis factor before it can issue its call for reinforcements. The COX-2 inhibitors target prostaglandin production, limiting pain and inflammation. And the blood-filtration device, invented at Cypress Bioscience of San Diego, strips the blood of proteins that tell white cells (erroneously) what tissues to attack--a treatment so effective in clinical trials that the FDA review-and-approval process has been put on a faster track...
Want to jump into this group with me? First, make sure you can handle the pain that's going to come before the gain. Understand that a lot of investors who took capital gains earlier this year are going to be looking to offset those gains with losses between now and year's end, for tax purposes. They're going to sell some of their losers, including oil-service stocks. So while these stocks are attractive now--otherwise, remember, insiders wouldn't be buying--their prices might well go lower before they go higher. Decide how much you want...
...altogether rarer. In John Burnham Schwartz's swift, smooth second novel, Reservation Road (Knopf; 292 pages; $24), the three-sided relationship between Ethan Learner, a pacifist English professor; his wife Grace, a trusting garden designer; and Dwight Arno, a temperamental probate lawyer, converges on a common point of pain: the hit-and-run death of 10-year-old Josh Learner, Ethan and Grace's music-prodigy son, at the cold steel hands of Dwight's Ford Taurus. The death is an accident, all blood and vectors, but the dark, emotional dance that follows is shown to be as inevitable...