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...seek natural pleasures like food and sex. These rewarding experiences trigger the release of the neurotransmitter dopamine - the brain's "do it again" signal. Over time, addicts' brains become narrowly focused on drug-related pleasures and hypersensitive to cues associated with them, such as seeing an old drinking pal. Hanging out with that friend would prompt a rise in dopamine levels in the brain's reward system. Researchers think that's where baclofen cuts in: by binding to the GABA-B receptor in the brain, it modulates this system and prevents the release of dopamine in response to cues. That...

Author: /time Magazine | Title: Treating Alcohol Addiction: A Pill Instead of Abstinence? | 7/29/2009 | See Source »

...week to break up his long, stressful office hours, decided this spring to have a shower installed in his company's headquarters. Gage did not react well to the first contractor's estimate of $14,000: "I say, 'Are you nuts? I'm not paying your country-club dues, pal.' He drops the bid to $4,400." But Gage got another estimate, from his receptionist's husband, for $1,100. "He wins, and he does a super job, top notch. The first contractor comes back to see how it went. He doesn't say much, other than that a couple...

Author: /time Magazine | Title: Tables Turned: Contractors Now at Homeowners' Mercy | 7/28/2009 | See Source »

...Sharp, his personal attorney in the Plame case, who had been present when he was interviewed by Fitzgerald in 2004. Sharp was known in Washington as one of the best lawyers nobody knew. A savvy raconteur from Oklahoma who had represented a long list of colorful clients - from Nixon pal Charles G. (Bebe) Rebozo to Sammy Sosa - Sharp had worked quietly for the President for a while before anyone even knew about it. In the meantime, the two men had become friends, spending hours chatting over cigars and near beer. On the Sunday before he left office, Bush invited Sharp...

Author: /time Magazine | Title: Inside Bush and Cheney's Final Days | 7/24/2009 | See Source »

...That's sex in a very PG, Potter fashion. The "snogging" engaged in by the 16-year-olds has a chaste, comic choreography, as if kissing were a minuet of locked lips. When Harry (Daniel Radcliffe) and his pal Ron Weasley (Rupert Grint) talk furtively about the girls they're mad for, it's to acknowledge vaguely that they have "nice skin." And when our hero's notoriety makes the Hogwarts girls just wild about Harry, his friend-girl Hermione (Emma Watson) can't suppress a little sulfur puff of rancor. "She's only interested in you," Hermione snits about...

Author: /time Magazine | Title: Harry Potter: Darker, Richer and All Grown Up | 7/15/2009 | See Source »

Travelers like the erudite British naturalist Redmond O'Hanlon used to come to these parts in search of untouched rainforest and unadulterated indigenous life. His Into the Heart of Borneo recounts a 1983 attempt, with poet pal James Fenton, to "rediscover" the Borneo rhinoceros near Sarawak's mountainous border with Indonesia. O'Hanlon describes wild dance parties at Dayak longhouses, fueled by gallons of tuak, a potent milky rice wine, and enthuses about jaw-dropping tangles of tropical growth along the Rajang and its watery veins, some walled in by lush, 200-ft.-high (60 m) tree canopies...

Author: /time Magazine | Title: Ebb and Flow in Borneo | 7/15/2009 | See Source »

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