Word: panicali
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Most vaccine production is carried out by five major pharmaceutical companies: Merck, Smith-Kline Beecham, Connaught, Merieux and Medeva. But according to Dennis Panicali, president and CEO of the Cambridgebased Therion Biologics Corporation, it's the small biotechnology firms which are experimenting with more novel techniques for producing vaccines...
...Biotech companies have a role in being able to accept a greater risk," Panicali says. "Large pharmaceutical companies cannot assume [as much risk] because of their obligations to their stockholders...
...biotech firms and pharmaceutical companies also work in conjunction with university based researchers. Panicali said his company has worked in conjunction with investigators at Harvard, the University of Massachusetts and Ohio State University...
What Paoletti and his colleague, Virologist Dennis Panicali, set out to do was to alter the genetic material, or DNA, of cowpox virus by inserting a gene from another virus-herpes, hepatitis B or influenza (see diagram). The goal of these microscopic manipulations is to develop a vaccine that will fool the immune system and make it swing into action. A smallpox preventive that expresses a herpes trait, for instance, will provoke the body into creating antibodies against herpes. The person is then protectively armed against an actual attack of the disease...
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