Word: papanicolaou
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...rest, whatever the percentage, Dr. Wilson is an all-out advocate of hormone replacement therapy, preferably beginning as early as age 30. With proper professional caution, he insists that a woman should take hormones only under a doctor's care, and should have a Papanicolaou smear test every year. The test serves a dual purpose: besides being a precautionary check for early cancer, the smear is read to show what percentage of the woman's vaginal cells are healthy, prime-of-life types, as compared with the cells of old age. Dr. Wilson calls this "the femininity index...
...uterus used to be the most common site of fatal cancer in women. Today, thanks mainly to early detection with the Papanicolaou smear, it is far less deadly. "With 44,000 new cases expected next year, there will be an estimated 14,000 deaths. The A.C.S. believes that an annual "Pap" smear test for all 58 million women...
Probably no man has done more to save lives threatened by cancer than Greek-born Dr. George N. Papanicolaou. 76, of Cornell University Medical College, who devised a test for cancer of the uterus and cervix by smearing mucous secretion on a glass slide and examining the stained cells under a microscope. The "Pap smear" is nc' done routinely in hundreds of U.S. laboratories, for an estimated total of 3.000,000 tests a year-most of them for healthy women wisely having regular examinations. Vast ingenuity has gone into extensions of the Pap test: aerosols to make a smoker...
...years ago, cancer was detected by the crude method of waiting for an obvious malignancy to appear. Then Dr. George Papanicolaou of Cornell University Medical College devised his revolutionary method of early detection: smearing body secretions on glass slides for microscopic study of cells. In thousands of doctors' offices, the now standard Papanicolaou technique is to stain cells with polychrome dyes. Seen in the visible spectrum of light, the dyes readily emphasize the structure of malignant cells...
...technique is the exceptional clarity that acridine orange gives to a malignant cell: it glows sharply in a field of normal cells. When the Army team tested 4,995 cervical and vaginal smears with acridine orange, they detected 171 "suspicious" cases compared to 156 in a retest by the Papanicolaou technique. When they later did biopsies on nine of the 15 Papanicolaou "negatives," they found cancer in seven cases. This does not necessarily mean that the new method is more accurate. But it can definitely speed up cancer screening. At Walter Reed, cell-smear staining with acridine orange now takes...