Word: parkinson
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Dopamine, like most biologically important molecules, must be kept within strict bounds. Too little dopamine in certain areas of the brain triggers the tremors and paralysis of Parkinson's disease. Too much causes the hallucinations and bizarre thoughts of schizophrenia. A breakthrough in addiction research came in 1975, when psychologists Roy Wise and Robert Yokel at Concordia University in Montreal reported on the remarkable behavior of some drug-addicted rats. One day the animals were placidly dispensing cocaine and amphetamines to themselves by pressing a lever attached to their cages. The next they were angrily banging at the lever like...
...treatment become. For instance, the discovery by Fowler and her team that a chemical that inhibits the mopping-up enzyme MAO B may play a role in cigarette addiction has already opened new possibilities for therapy. A number of well-tolerated MAO B-inhibitor drugs developed to treat Parkinson's disease could find a place in the antismoking arsenal. Equally promising, a Yale University team led by Eric Nestler and David Self has found that another type of compound--one that targets the dopamine receptor known as D1--seems to alleviate, at least in rats, the intense craving that accompanies...
...scientists have begun to do just that. A report published last week in the New England Journal of Medicine shows for the first time that the mental deterioration of Alzheimer's can be slowed significantly by two common drugs: vitamin E and selegiline, a compound used to treat Parkinson's disease. The two-year study conducted by the National Institute on Aging showed that normal doses of selegiline or high doses of vitamin E, both of which are antioxidants, slowed the rate of disability among patients with moderately severe Alzheimer's by an average of seven months. Neither drug reversed...
When this frail old man finally succumbed to the Parkinson's disease and lung ailments that had sparked rumors of his demise for years, most Chinese registered barely a sigh. Black-clad television announcers proclaimed his death just a few hours after it occurred, while traffic continued to thread through Tiananmen Square. The casual manner in which Beijing residents went about their daily routines offered eloquent proof that the Chinese have accepted their leader's mortality and long since discounted his loss. "We are at ease with the thought that things will be all right without Deng," said Beijing writer...
...supporting cast. But two other characters hover above When We Were Kings like the Ghosts of Kinshasa Future: the Foreman and Ali of today. One became a preacher and found a rich comic voice that has finally made him an endearing figure in sports. The other is afflicted with Parkinson's syndrome, his grace palsied, his old raffish rhetoric muted. The King is a physical pauper now, and at his sight we age and ache. His mind, however, is not so impaired, nor is his taste for raillery. Ali recently saw the film and phoned Gast to express his appreciation...