Word: pathogenicity
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...Listeria is a much tougher pathogen than some others,” Glickman said. “It worries...
...parts. The first involves antibodies, the molecules produced to match, like a key fitting into a lock, the multiple proteins that coat the surfaces of viruses and bacteria. The more keys on the immune cell's ring, the more likely that the cell can lock onto and destroy a pathogen...
...Dallas, is using medicine's newfound skill at sequencing genomes to figure out precisely what genes express, or turn on, when a bug first enters a host's cells. Using microarrays, also known as "DNA chips," Johnston is working to identify those genes, then snip them from a pathogen's genome and use them, or the proteins they make, as vaccines to trigger an immune response...
Cancer would seem to be the last disease you could prevent or treat with a vaccine. After all, infection plays no role in cancer, except in a few rare types of malignancy. And a cancer cell, unlike an invading pathogen, isn't wholly foreign to the body. Nevertheless, researchers are learning that the immune system can even be trained to go after tumors. CanVaxin, for example, a vaccine for the deadly skin cancer melanoma, is made from cancer-cell lines taken from three different patients; among them, they express more than 20 disabled tumor antigens that the immune system...
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