Word: pathways
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...turns out that Gleevec was a Cinderella story - a perfect matching of drug to cancer. The specific cancers for which Gleevec has wrought such miracles - chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST) - rely pretty exclusively on a pathway that Gleevec targets, making these diseases ideal victims for a targeted therapy. But breast, lung, colon and prostate cancers, the leading types of cancer in the U.S., aren't as accommodating...
...full of just such compounds. So far, the best cocktails, still in early testing in the most advanced cancer patients, try to include some agents aimed at cutting off a tumor's blood supply (so-called angiogenesis inhibitors), others designed to trigger a cancer cell's pre-programmed suicide pathway, or still other compounds that muck up the intricate signaling system that a cancer cell uses to guide and control its growth. Scientists are also turning their attention to metastasis, which is responsible for over 90% of the deaths from solid tumor cancers, by finding the genes and pathways responsible...
...against Harris Miller, a longtime party activist and telecommunications-industry lobbyist. And it's strange: Webb's Democratic bona fides are the big question in the June 13 election, but he refuses to offer a pat answer. He wanders through his response, talking as a writer thinks, trying one pathway, then another--and it requires some patience from the audience, which is used to hearing politicians give smooth, market-tested replies to the tough questions. But the patience is rewarded. Webb has taken a spiritual journey over the past decade, launched by the research he did for Born Fighting...
...Security Council. Meanwhile, Tehran has sped up research work on the uranium enrichment that lies at the heart of the dispute. Diplomats who have been briefed on Iran's program by international inspectors say the country has developed the ability to enrich uranium, the first step on the pathway to the Bomb. "They're progressing much faster than we thought they would," says a knowledgeable U.S. official. "They seem to know what they're doing...
...measuring the current that flows across the sperm’s plasma membrane for the first time, Yuriy V. Kirichok and Betsy Navarro of the Children’s Hospital in Boston, found that sperm have a unique ion pathway. The discovery allowed Kirichok and Navarro to determine the function of the cation channel of sperm (CatSper) and could potentially lead to the development of new contraceptives designed to block the protein...